DS-437
Cat. No.:YN310173
CAS No. :1674364-87-4
产品名称: | DS-437 |
CAS No.: | 1674364-87-4 |
Chemical Name: | 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-adenosine |
Synonyms: | BDBM50089221;1-(2-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)ethyl)-3-ethylurea;5 inverted exclamation marka-S-[2-[[(Ethylamino)carbonyl]amino]ethyl]-5 inverted exclamation marka-thioadenosine;1-[2-[[(2S,3S,4R |
分子量: | 397.45 |
分子式: | C₁₅H₂₃N₇O₄S |
SMILES: | O[C@@H]([C@H]([C@H](N1C=NC2=C(N=CN=C21)N)O3)O)[C@H]3CSCCNC(NCC)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | DS-437 是双重蛋白精氨酸甲基转移酶PRMT5/7抑制剂,对两者的IC50均为 6 μM。 与其他 29 种人类蛋白质,DNA 和 RNA 甲基转移酶相比,DS-437 对 PRMT5 和 PRMT7 具有选择性。DS-437是 SAM 竞争性抑制剂。DS-437 还抑制 DNMT3A 和 DNMT3B,IC50分别为 52 和 62 μM。DS-437 抑制 FOXP3 的甲基化。 |
IC50和靶点: | |
In Vitro: | |
In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Smil, D., Eram, M.S., Li, F., et al.Discovery of a dual PRMT5-PRMT7 inhibitorACS Med. Chem. Lett.6(4),408-412(2015)
Nagai, Y., Ji, M.Q., Zhu, F., et al.PRMT5 associates with the FOXP3 homomer and when disabled enhances targeted p185erbB2/neu tumor immunotherapyFront. Immunol.10:174,(2019)