CEP-40783
Cat. No.：YN440025
CAS No. ：1437321-24-8
规格
价格(RMB)
库存
| 产品名称: | CEP-40783 |
| CAS No.: | 1437321-24-8 |
| Chemical Name: | N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-5-pyrimidinecarboxamide |
| Synonyms: | RXDX-106 |
| 分子量: | 588.56 |
| 分子式: | C₃₁H₂₆F₂N₄O₆ |
| SMILES: | O=C(C1=CN(C(C)C)C(N(C2=CC=C(F)C=C2)C1=O)=O)NC3=CC=C(OC4=CC=NC5=CC(OC)=C(OC)C=C45)C(F)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CEP-40783是高效选择性，有口服活性的AXL和c-Met抑制剂，IC50值分别为7 nM 和12 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Miknyoczki, S.J., Cheng, M., Hudkins, R., et al.CEP-40783: A potent and selective AXL/c-Met inhibitor for use in breast, non-small cell lung (NSCLC), and pancreatic cancersMol. Cancer Ther.12(11 Suppl),C275(2013)
Yokoyama, Y., Lew, E.D., Seelige, R., et al.Immuno-oncological efficacy of RXDX-106, a novel TAM (TYRO3, AXL, MER) family small-molecule kinase inhibitorCancer Res.79(8),1996-2008(2019)
