Merestinib
Cat. No.：YN440331
CAS No. ：1206799-15-6
规格
价格(RMB)
库存
| 产品名称: | Merestinib |
| CAS No.: | 1206799-15-6 |
| Chemical Name: | N-[3-fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxamide |
| Synonyms: | LY2801653 |
| 分子量: | 552.53 |
| 分子式: | C₃₀H₂₂F₂N₆O₃ |
| SMILES: | O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Merestinib (LY2801653) 是一种有效的口服生物可利用的具有抗肿瘤活性的c-Met抑制剂 (Ki=2 nM)。Merestinib (LY2801653) 对 MST1R (IC50=11 nM)、FLT3 (IC50=7 nM)、AXL (IC50=2 nM)、MERTK (IC50=10 nM)、TEK (IC50=63 nM)、ROS1、DDR1/2 (IC50=0.1/7 nM) 和 MKNK1/2 (IC50=7 nM) 也有较强的活性。 |
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Yan, S.B., Peek, V.L., Ajamie, R., et al.LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft modelsInvest New Drugs31(4),833-844(2013)
