SGX-523
Cat. No.：YN440183
CAS No. ：1022150-57-7
规格
价格(RMB)
库存
| 产品名称: | SGX-523 |
| CAS No.: | 1022150-57-7 |
| Chemical Name: | 6-[[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-quinoline |
| Synonyms: | SGX523; SGX 523 |
| 分子量: | 359.41 |
| 分子式: | C₁₈H₁₃N₇S |
| SMILES: | CN1N=CC(C2=NN3C(SC4=CC5=C(N=CC=C5)C=C4)=NN=C3C=C2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SGX-523是Met抑制剂，IC50为4 nM，对BRAFV599E，c-Raf，Abl和p38α无活性。 |
| IC50和靶点: | |
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Buchanan, S.G., Hendle, J., Lee, P.S., et al.SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivoMol. Cancer Ther.8(12),3181-3190(2009)
Padda, S., Neal, J.W., and Wakelee, H.A.MET inhibitors in combination with other therapies in non-small cell lung cancerTransl. Lung Cancer Res.1(4),238-253(2012)
Guessous, F., Zhang, Y., diPierro, C., et al.An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growthAnticancer Agents Med. Chem.10(1),28-35(2010)
Zhang, Y.W., Staal, B., Essenburg, C., et al.Strengthening context-dependent anticancer effects on non-small cell lung carcinoma by inhibition of both MET and EGFRMol. Cancer Ther.12(8),1429-1441(2013)
Diamond, S., Boer, J., Maduskuie, T.P., Jr., et al.Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implicationsDrug Metab. Dispos.38(8),1277-1285(2010)
