SAR125844
Cat. No.：YN440362
CAS No. ：1116743-46-4
规格
价格(RMB)
库存
| 产品名称: | SAR125844 |
| CAS No.: | 1116743-46-4 |
| Chemical Name: | N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N′-[2-(4-morpholinyl)ethyl]-urea |
| Synonyms: | SAR125884 |
| 分子量: | 550.63 |
| 分子式: | C₂₅H₂₃FN₈O₂S₂ |
| SMILES: | O=C(NCCN1CCOCC1)NC2=NC3=CC=C(SC4=NN=C5C=CC(C6=CC=C(F)C=C6)=NN54)C=C3S2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SAR125844 是一种有效的、高度选择性的、可逆的、ATP竞争性的MET受体酪氨酸激酶 (RTK)的抑制剂，其IC50值为4.2 nM。能抑制细胞中MET的自磷酸化。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ugolini, A., Kenigsberg, M., Rak, A., et al.Discovery and pharmacokinetic and pharmacological properties of the potent and selective MET kinase inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844)J. Med. Chem.59(15),7066-7074(2016)
Egile, C., Kenigsberg, M., Delaisi, C., et al.The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancerMol. Cancer Ther.14(2),384-394(2015)
