BMS 777607
Cat. No.：YN440194
CAS No. ：1025720-94-8
规格
价格(RMB)
库存
| 产品名称: | BMS 777607 |
| CAS No.: | 1025720-94-8 |
| Chemical Name: | N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide |
| Synonyms: | BMS 817378 |
| 分子量: | 512.89 |
| 分子式: | C₂₅H₁₉ClF₂N₄O₄ |
| SMILES: | O=C(NC1=CC=C(C(F)=C1)OC2=C(C(N)=NC=C2)Cl)C3=C(C=CN(C3=O)C4=CC=C(C=C4)F)OCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS 777607 是一种Met-related抑制剂，能够抑制c-Met，Axl，Ron和Tyro3的活性，IC50值为 3.9 nM，1.1 nM，1.8 nM 和 4.3 nM。 |
| IC50和靶点: | |
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Sharma, S., Zeng, J.Y., Zhuang, C.M., et al.Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agentsMol. Cancer Ther.12(5),725-736(2013)
Dai, Y., and Siemann, D.W.BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitroMol. Cancer Ther.9(6),1554-1561(2010)
