Golvatinib
Cat. No.：YN440248
CAS No. ：928037-13-2
规格
价格(RMB)
库存
| 产品名称: | Golvatinib |
| CAS No.: | 928037-13-2 |
| Chemical Name: | N-[2-fluoro-4-[[2-[[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]amino]-4-pyridinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
| Synonyms: | E-7050 |
| 分子量: | 633.69 |
| 分子式: | C₃₃H₃₇F₂N₇O₄ |
| SMILES: | O=C(NC1=CC=C(C=C1F)OC2=CC(NC(N3CCC(CC3)N4CCN(CC4)C)=O)=NC=C2)C5(CC5)C(NC6=CC=C(C=C6)F)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Golvatinib (E-7050) 是c-Met和VEGFR2的双重抑制剂，IC50值分别为14 和 16 nM。 |
| IC50和靶点: | [{name:"VEGFR2:16 nM (IC50)"},{name: "c-Met:14 nM (IC50)"}] |
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| Solvent & Solubility: |
Nakagawa, T., Tohyama, O., Yamaguchi, A., et al.E7050: A dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft modelsCancer Sci.101(1),210-215(2010)
