LLY-283
Cat. No.：YN310086
CAS No. ：2040291-27-6
| 产品名称: | LLY-283 |
| CAS No.: | 2040291-27-6 |
| Chemical Name: | 7-[(5R)-5-C-phenyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Synonyms: | LLY283 |
| 分子量: | 342.35 |
| 分子式: | C₁₇H₁₈N₄O₄ |
| SMILES: | O[C@H]1[C@@H](O[C@@]([C@@H](C2=CC=CC=C2)O)([H])[C@H]1O)N3C4=NC=NC(N)=C4C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LLY-283 是一种有效的，选择性的，可口服的蛋白精氨酸甲基转移酶 5 (PRMT5) 抑制剂，对 PRMT5:MEP50 复合物的作用很强，IC50和Kd值分别为 22 nM 和 6 nM，具有抗肿瘤活性。 |
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Bonday, Z.Q., Cortez, G.S., Grogan, M.J., et al.LLY-283, a potent and selective inhibitor of arginine methyltransferase 5, PRMT5, with antitumor activityACS Med. Chem. Lett.9(7),612-617(2018)
Sachamitr, P., Ho, J.C., Ciamponi, F.E., et al.PRMT5 inhibition disrupts splicing and stemness in glioblastomaNat. Commun.12(1),979(2021)
