E7449
Cat. No.：YN290194
CAS No. ：1140964-99-3
| 产品名称: | E7449 |
| CAS No.: | 1140964-99-3 |
| Chemical Name: | 8-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-1,2-dihydro-3H-pyridazino[3,4,5-de]quinazolin-3-one |
| Synonyms: | UNII-9X5A2QIA7C |
| 分子量: | 317.34 |
| 分子式: | C₁₈H₁₅N₅O |
| SMILES: | O=C1NNC2=C3C1=CC=CC3=NC(CN4CC5=C(C=CC=C5)C4)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | E7449 是PARP1和PARP2的有效抑制剂，同时可抑制TNKS1和TNKS2的活性，在以32P-NAD+为底物的实验中，测得对 PARP1，PARP2，TNKS1 和 TNKS2 的IC50值分别为 2.0，1.0，∼50 和 ∼50 nM。 |
| IC50和靶点: | [{name:"PARP2:1 nM (IC50)"},{name: "PARP1:2 nM (IC50)"},{name: "TNKS1:50 nM (IC50)"},{name: "TNKS2:50 nM (IC50)"}] |
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McGonigle, S., Chen, Z., Wu, J., et al.E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signalingOncotarget6(38),41307-41323(2015)
