NMS-P118
Cat. No.：YN310309
CAS No. ：1262417-51-5
| 产品名称: | NMS-P118 |
| CAS No.: | 1262417-51-5 |
| Chemical Name: | 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide |
| Synonyms: | NMS-P118; NMS-P 118; NMS P118 |
| 分子量: | 395.42 |
| 分子式: | C₂₀H₂₄F₃N₃O₂ |
| SMILES: | FC(CC1)(F)CCC1N(CC2)CCC2N(C3=O)CC4=C3C(C(N)=O)=CC(F)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NMS-P118是一种有效的，口服可用的，高选择性的PARP-1抑制剂，在HeLa细胞中的IC50值为0.04 μM。 |
| IC50和靶点: | [{name:"PARP-1:9 nM (Kd)"},{name: "PARP-2:1390 nM (Kd)"}] |
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Papeo, G., Posteri, H., Borghi, D., et al.Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A potent, orally available, and highly selective PARP-1 inhibitor for cancer therapyJ. Med. Chem.58(17),6875-6898(2015)
Javle, M., and Curtin, N.J.The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapyTher. Adv. Med. Oncol.3(6),257-267(2011)
