WIKI4
Cat. No.：YN310299
CAS No. ：838818-26-1
| 产品名称: | WIKI4 |
| CAS No.: | 838818-26-1 |
| Chemical Name: | 2-[3-[[4-(4-methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione |
| Synonyms: | wiki 4 |
| 分子量: | 521.59 |
| 分子式: | C₂₉H₂₃N₅O₃S |
| SMILES: | O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WIKI4 是一种有效的tankyrase抑制剂，其对TNKS2的IC50值为 26 nM。WIKI4 有效抑制Wnt/β-catenin信号传导，其EC50值为 75 nM。WIKI4 通过抑制TNKS2的酶活性来介导其对Wnt/β-catenin信号传导的影响。WIKI4 对 SCLC 细胞具有细胞毒性，其IC50值为 0.02 μM。 |
| IC50和靶点: | [{name:"TNKS2:26 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
James, R.G., Davidson, K.C., Bosch, K.A., et al.WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signalingPLoS One7(12),1-10(2012)
Haikarainen, T., Venkannagari, H., Narwal, M., et al.Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4PLoS One8(6),1-8(2013)
