JW 55
Cat. No.：YN310253
CAS No. ：664993-53-7
| 产品名称: | JW 55 |
| CAS No.: | 664993-53-7 |
| Chemical Name: | N-[4-[[[[tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide |
| Synonyms: | JW55 |
| 分子量: | 434.48 |
| 分子式: | C₂₅H₂₆N₂O₅ |
| SMILES: | O=C(C1=CC=CO1)NC2=CC=C(C(NCC3(C4=CC=C(OC)C=C4)CCOCC3)=O)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JW 55 是一种有效的选择性β-catenin抑制剂，通过抑制端锚聚合酶 (tankyrase 1 和 tankyrase 2，TNKS1/2) 发挥作用。 |
| IC50和靶点: | [{name:"TNKS2:0.83 μM (IC50)"},{name: "TNKS1:1.9 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Waaler, J., Machon, O., Tumova, L., et al.A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant miceCancer Res.72(11),2822-2832(2012)
