NVP-TNKS656
Cat. No.：YN310255
CAS No. ：1419949-20-4
| 产品名称: | NVP-TNKS656 |
| CAS No.: | 1419949-20-4 |
| Chemical Name: | N-(cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidineacetamide |
| Synonyms: | TNKS656 |
| 分子量: | 494.58 |
| 分子式: | C₂₇H₃₄N₄O₅ |
| SMILES: | O=C(N(CC1CC1)CC2=NC3=C(COCC3)C(N2)=O)CN4CCC(C(C5=CC=C(OC)C=C5)=O)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVP-TNKS656 是一种有效的，可口服的，选择性的TNKS2抑制剂，IC50值为 6 nM，是PARP1和PARP2的选择性的 300 多倍。 |
| IC50和靶点: | [{name:"TNKS2:6 nM (IC50)"},{name: "PARP2:32 μM (IC50)"}] |
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| Solvent & Solubility: |
Shultz, M.D., Cheung, A.K., Kirby, C.A., et al.Identification of NVP-TNKS656: The use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitorJ. Med. Chem.56(16),6495-6511(2013)
