BYK204165
Cat. No.：YN310097
CAS No. ：1104546-89-5
| 产品名称: | BYK204165 |
| CAS No.: | 1104546-89-5 |
| Chemical Name: | 4-[(1-methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione |
| Synonyms: | RT-017290 |
| 分子量: | 252.27 |
| 分子式: | C₁₅H₁₂N₂O₂ |
| SMILES: | O=C1NC(/C(C2=C1C=CC=C2)=C\C3=CC=CN3C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BYK204165 是一种有效的选择性PARP1抑制剂。BYK204165 抑制重组人 PARP-1 (hPARP-1)，pIC50值为 7.35 (pKi7.05)。抑制鼠 PARP-2 (mPARP-2)，pIC50值为 5.38 。BYK204165 对 PARP-1 的选择性比对 PARP-2 高 100 倍。 |
| IC50和靶点: | [{name:"hPARP-1:7.35 (pIC50)"},{name: "mPARP-2:5.38 (pIC50)"}] |
| In Vitro: | |
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| Solvent & Solubility: |
Eltze, T., Boer, R., Wagner, T., et al.Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): A comparison with standard PARP inhibitorsMol. Pharmacol.74(6),1587-1598(2008)
