AZD-2461
Cat. No.：YN310223
CAS No. ：1174043-16-3
| 产品名称: | AZD-2461 |
| CAS No.: | 1174043-16-3 |
| Chemical Name: | 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone |
| Synonyms: | AZD2461;4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one;4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one;AZD 2461;AZD-2461;1(2H)-Phthalazinone,4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl |
| 分子量: | 395.43 |
| 分子式: | C₂₂H₂₂FN₃O₃ |
| SMILES: | O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(OC)CC3)=O)=C2)C4=C1C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD-2461 是一种有效的PARP抑制剂，可抑制 PARP1，PARP2 和 PARP3 的活性，IC50值分别为 5 nM，2 nM 和 200 nM。 |
| IC50和靶点: | [{name:"PARP2:2 nM (IC50)"},{name: "PARP1:5 nM (IC50)"},{name: "PARP3:200 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Jaspers, J.E., Kersbergen, A., Boon, U., et al.Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumorsCancer Discov.3(1),68-81(2013)
