RK-287107
Cat. No.：YN310167
CAS No. ：2171386-10-8
| 产品名称: | RK-287107 |
| CAS No.: | 2171386-10-8 |
| Chemical Name: | 2-[4,6-difluoro-1-(2-hydroxyethyl)spiro[3H-indole-3,4′-piperidine]-1′(2H)-yl]-5,6,7,8-tetrahydro-4(3H)-quinazolinone |
| Synonyms: | RK287107;RK 287107 |
| 分子量: | 416.46 |
| 分子式: | C₂₂H₂₆F₂N₄O₂ |
| SMILES: | O=C1NC(N2CCC3(CC2)CN(CCO)C4=C3C(F)=CC(F)=C4)=NC5=C1CCCC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RK-287107 是一种有效的特异性tankyrase抑制剂，抑制tankyrase-1和tankyrase-2，IC50分别为 14.3 和 10.6 nM。RK-287107 可阻断结直肠癌细胞生长。 |
| IC50和靶点: | [{name:"tankyrase-1:14.3 nM (IC50)"},{name: "tankyrase-2:10.6 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shirai, F., Tsumura, T., Yashiroda, Y., et al.Discovery of novel spiroindoline derivatives as selective tankyrase inhibitorsJ. Med. Chem.62(7),3407-3427(2019)
