G007-LK
Cat. No.：YN290200
CAS No. ：1380672-07-0
| 产品名称: | G007-LK |
| CAS No.: | 1380672-07-0 |
| Chemical Name: | 4-[5-[(1E)-2-[4-(2-chlorophenyl)-5-[5-(methylsulfonyl)-2-pyridinyl]-4H-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol-2-yl]-benzonitrile |
| Synonyms: | G007LK;(E)-4-(5-(2-(4-(2-chlorophenyl)-5-(5-(methylsulfonyl)pyridin-2-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)benzonitrile;G007-LK;4-{5-[(E)-2-{4-(2-Chlorophenyl)-5-[5-(Methylsulfonyl)pyridin-2-Yl]-4h-1,2,4-Triazol-3-Yl}ethenyl]-1,3,4-Oxadia |
| 分子量: | 529.96 |
| 分子式: | C₂₅H₁₆ClN₇O₃S |
| SMILES: | ClC1=C(C=CC=C1)N2C(/C=C/C3=NN=C(C4=CC=C(C#N)C=C4)O3)=NN=C2C5=CC=C(S(C)(=O)=O)C=N5.[(E)] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | G007-LK 是一种有效的，选择性的TNKS1和TNKS2抑制剂，IC50值分别为 46 nM 和 25 nM。 |
| IC50和靶点: | [{name:"TNKS2:25 nM (IC50)"},{name: "TNKS1:46 nM (IC50)"}] |
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| Solvent & Solubility: |
Voronkov, A., Holsworth, D.D., Waaler, J., et al.Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitorJ. Med. Chem.56(7),3012-3023(2013)
Lau, T., Chan, E., Callow, M., et al.A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growthCancer Res.73(10),3132-3144(2013)
Jia, J., Quao, Y., Pilo, M.G., et al.Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascadePLoS One12(9),e0184068(2017)
