RBN012759
Cat. No.：YN290285
CAS No. ：2360851-29-0
| 产品名称: | RBN012759 |
| CAS No.: | 2360851-29-0 |
| Chemical Name: | 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-4(3H)-quinazolinone |
| Synonyms: | |
| 分子量: | 378.46 |
| 分子式: | C₁₉H₂₃FN₂O₃S |
| SMILES: | O=C1NC(CS[C@H]2CC[C@H](O)CC2)=NC3=C1C(F)=CC(OCC4CC4)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RBN012759 是一种有效的，选择性和具有口服活性的PARP14抑制剂，IC50值 <3 nM，比对 monoPARPs 的选择性高 300 倍，比对 polyPARPs 的选择性高 1000 倍。RBN012759 可以降低肿瘤前巨噬细胞的功能并引起肿瘤外植体的炎症反应。 |
| IC50和靶点: | [{name:"PARP14:<3 nM (IC50)"},{name: "PARP4:10 μM (IC50)"},{name: "PARP5a:8 μM (IC50)"},{name: "PARP5b:10 μM (IC50)"},{name: "PARP6:4 μM (IC50)"},{name: "PARP7:4 μM (IC50)"},{name: "PARP8:20 μM (IC50)"},{name: "PARP10:1 μM (IC50)"},{name: "PARP11:1 μM (IC50)"},{name: "PARP12:5 μM (IC50)"},{name: "PARP15:3 μM (IC50)"},{name: "PARP16:6 μM (IC50)"}] |
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| Solvent & Solubility: |
Schenkel, L.B., Molina, J.R., Swinger, K.K., et al.A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explantsCell Chem. Biol.28(8),1158-1168.e1113(2021)
