BGP-15
Cat. No.：YN310028
CAS No. ：66611-37-8
| 产品名称: | BGP-15 |
| CAS No.: | 66611-37-8 |
| Chemical Name: | N-[2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride |
| Synonyms: | BGP15,BGP-15 2HCl |
| 分子量: | 351.27 |
| 分子式: | C₁₄H₂₄Cl₂N₄O₂ |
| SMILES: | N=C(C1=CC=CN=C1)NOCC(O)CN2CCCCC2.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BGP-15 是一种PARP抑制剂，IC50和Ki值分别为 120 和 57 μM。 |
| IC50和靶点: | [{name:"PARP:120 μM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Davar, D., Beumer, J.H., Hamieh, L., et al.Role of PARP inhibitors in cancer biology and therapyCurr. Med. Chem.19(23),3907-3921(2012)
Halmosi, R., Berente, Z., Osz, E., et al.Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in langendorff heart perfusion systemMol. Pharmacol.59(6),1497-1505(2001)
Szabados, E., Literati-Nagy, P., Farkas, B., et al.BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymeraseBiochem. Pharmacol.59(8),937-945(2000)
Chung, J., Nguyen, A.K., Henstridge, D.C., et al.HSP72 protects against obesity-induced insulin resistanceProc. Natl. Acad. Sci. USA105(5),1739-1744(2008)
Henstridge, D.C., Bruce, C.R., Drew, B.G., et al.Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistanceDiabetes63,1881-1894(2014)
