Niraparib hydrochloride
Cat. No.：YN310077
CAS No. ：1038915-64-8
规格
价格(RMB)
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| 产品名称: | Niraparib hydrochloride |
| CAS No.: | 1038915-64-8 |
| Chemical Name: | |
| Synonyms: | MK-4827 hydrochloride |
| 分子量: | 356.85 |
| 分子式: | C₁₉H₂₁ClN₄O |
| SMILES: | NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C21)=O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Niraparib hydrochloride (MK-4827 hydrochloride) 是一种有效的，具有口服活性的PARP1和PARP2抑制剂，IC50值分别为 3.8 nM 和 2.1 nM。Niraparib hydrochloride 抑制 DNA 损伤修复，诱导凋亡 (apoptosis) 并具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"PARP-2:2.1 nM (IC50)"},{name: "PARP-1:3.8 nM (IC50)"},{name: "V-PARP:330 nM (IC50)"},{name: "TANK-1:570 nM (IC50)"},{name: "PARP-3:1300 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
