Ailanthone
Cat. No.：YN482727
CAS No. ：981-15-7
| 产品名称: | Ailanthone |
| CAS No.: | 981-15-7 |
| Chemical Name: | (1β,11β,12α)-11,20-epoxy-1,11,12-trihydroxy-picrasa-3,13(21)-diene-2,16-dione |
| Synonyms: | Δ13-Dehydrochaparrinone |
| 分子量: | 376.40 |
| 分子式: | C₂₀H₂₄O₇ |
| SMILES: | C[C@@]1([C@@H]2O)[C@]([C@@]3([C@@H]4O)O)([H])[C@@]([C@](C5)([H])C4=C)(CO3)[C@@](OC5=O)([H])C[C@@]1([H])C(C)=CC2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ailanthone (Δ13-Dehydrochaparrinone) 是有效的雄激素受体 (androgen receptor (AR)) 抑制剂， 抑制完整雄激素受体，和持续活跃剪切变体的IC50值分别为 69 nM 和309 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Okunade, A.L., Bikoff, R.E., Casper, S.J., et al.Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae)Phytother. Res.17(6),675-677(2003)
De Feo, V., De Martino, L., Quaranta, E., et al.Isolation of phytotoxic compounds from tree-of-heaven (Ailanthus altissima swingle)J. Agric. Food Chem.51(5),1177-1180(2003)
He, Y., Peng, S., Wang, J., et al.Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancerNat. Commun.7:13122,(2016)
