GLPG0492
Cat. No.：YN481618
CAS No. ：1215085-92-9
规格
价格(RMB)
库存
| 产品名称: | GLPG0492 |
| CAS No.: | 1215085-92-9 |
| Chemical Name: | 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-benzonitrile |
| Synonyms: | GLPG0492 |
| 分子量: | 389.33 |
| 分子式: | C₁₉H₁₄F₃N₃O₃ |
| SMILES: | N#CC1=CC=C(N(C(N(C)[C@]2(CO)C3=CC=CC=C3)=O)C2=O)C=C1C(F)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GLPG0492 是一种非甾体选择性雄激素受体 (androgen receptor) 调节剂 (有效 12 nM)。GLPG0492 在肌肉骨骼疾病如肌萎缩和恶病质的研究方面具有潜在的潜力。 |
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Nique, F., Hebbe, S., Triballeau, N., et al.Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulatorJ. Med. Chem.55(19),8236-8247(2012)
Cozzoli, A., Capogrosso, R.F., Sblendorio, V.T., et al.GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophyPharmacol. Res.72,9-24(2013)
Blanqué, R., Lepescheux, L., Auberval, M., et al.Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilizationBMC Musculoskelet. Disord.15:291,(2014)
