MI-136
Cat. No.：YN481663
CAS No. ：1628316-74-4
规格
价格(RMB)
库存
| 产品名称: | MI-136 |
| CAS No.: | 1628316-74-4 |
| Chemical Name: | 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile |
| Synonyms: | MI-136;MI 136;5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile;5-[(4-{[6-(2,2,2-Trifluoroethyl)thieno[2,3-D]pyrimidin-4-Yl]amino}piperidin-1-Yl)methyl]-1h-Indole-2-Carbonitrile;PSOJDGBGVBEYJ |
| 分子量: | 470.51 |
| 分子式: | C₂₃H₂₁F₃N₆S |
| SMILES: | FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=CC=C(NC(C#N)=C5)C5=C4)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MI-136 是menin-MLL(PPI) 蛋白互作的抑制剂，其IC50值为31 nM，Kd值为23.6 nM。MI-136 可抑制 AR 信号通路，有用于去势抵抗性肿瘤的潜能。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Borkin, D., Pollock, J., Kempinska, K., et al.Property focused structure-based optimization of small molecule inhibitors of the protein-protein interaction between menin and mixed lineage leukemia (MLL)J. Med. Chem.59(3),892-913(2016)
Borkin, D., He, S., Miao, H., et al.Pharmacologic inhibition of the menin-MLL interaction blocks progression of MLL leukemia in vivoCancer Cell27(4),589-602(2015)
Malik, R., Khan, A.P., Asangani, I.A., et al.Targeting the MLL complex in castration-resistant prostate cancerNat. Med.21(4),344-352(2015)
