GTx-007
Cat. No.：YN480724
CAS No. ：401900-40-1
规格
价格(RMB)
库存
| 产品名称: | GTx-007 |
| CAS No.: | 401900-40-1 |
| Chemical Name: | (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide |
| Synonyms: | S-4 |
| 分子量: | 441.36 |
| 分子式: | C₁₉H₁₈F₃N₃O₆ |
| SMILES: | O=C([C@@](O)(COC1=CC=C(C=C1)NC(C)=O)C)NC2=CC=C(C(C(F)(F)F)=C2)[N+]([O-])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GTx-007 (S-4) 是具有口服活性的、选择性的非甾体受体雄激素受体(AR)调节剂 (SARM) 和部分激动剂，Ki为4 nM。GTx-007 (S-4) 是具有较强活性的、具有组织选择性的 SARM。 |
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Kearbey, J.D., Wu, D., Gao, W., et al.Pharmacokinetics of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro- 3-trifluoromethyl-phenyl)-propionamide in rats, a non-steroidal selective androgen receptor modulatorXenobiotica34(3),273-280(2004)
Gao, W., Reiser, P.J., Coss, C.C., et al.Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized ratsEndocrinology146(11),4887-4897(2005)
Girgis, C.M., Mokbel, N., and DiGirolamo, D.J.Therapies for musculoskeletal disease: Can we treat two birds with one stone?Curr.Osteoporos.Rep.12(2),142-153(2014)
Geyer, H., Schäzner, W., and Thevis, M.Anabolic agents: Recent strategies for their detection and protection from inadvertent dopingBr. J. Sports Med.48(10),820-826(2014)
