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Flutamide

Cat. No.:YN481772

  • CAS No. :13311-84-7

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    • 产品名称: Flutamide
      CAS No.: 13311-84-7
      Chemical Name: 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide
      Synonyms:氟他胺; SCH 13521
      分子量:276.21
      分子式:C₁₁H₁₁F₃N₂O₃
      SMILES:CC(C)C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Flutamide是抗雄激素化合物,能与其活性代谢物一起与雄激素受体相结合,Ki为55 nM,可作用于前列腺癌。
      IC50和靶点:
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      In Vivo:
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      Solvent & Solubility:
    • Shet, M.S., McPhaul, M., Fisher, C.W., et al.Metabolism of the antiandrogenic drug (flutamide) by human CYP1A2Drug Metab. Dispos.25(11),1298-1303(1997)

      Shi, Q., Wada, K., Ohkoshi, E., et al.Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgensBioorg. Med. Chem.20(13),4020-4031(2012)

      Nnane, I.P., Long, B.J., Ling, Y.Z., et al.Anti-tumour effects and pharmacokinetic profile of 17-(5'-isoxazolyl)androsta-4,16-dien-3-one (L-39) in mice: An inhibitor of androgen synthesisBr. J. Cancer83(1),74-82(2000)

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