AZD3514
Cat. No.：YN481530
CAS No. ：1240299-33-5
规格
价格(RMB)
库存
| 产品名称: | AZD3514 |
| CAS No.: | 1240299-33-5 |
| Chemical Name: | 1-[4-[2-[4-[1-[7,8-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]-4-piperidinyl]phenoxy]ethyl]-1-piperazinyl]-ethanone |
| Synonyms: | AZD 3514, AZD-3514 |
| 分子量: | 519.56 |
| 分子式: | C₂₅H₃₂F₃N₇O₂ |
| SMILES: | CC(N1CCN(CCOC2=CC=C(C3CCN(C4=NN5C(CC4)=NN=C5C(F)(F)F)CC3)C=C2)CC1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD3514是口服的雄激素受体负调节剂，Ki为2.2 μM，可降低AR蛋白的表达。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Bradbury, R.H., Acton, D.G., Broadbent, N.L., et al.Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancerBioorg. Med. Chem. Lett.23(7),1945-1948(2013)
Loddick, S.A., Ross, S.J., Thomason, A.G., et al.AZD3514: A small molecule that modulates androgen receptor signaling and function in vitro and in vivoMol. Cancer Ther.12(9),1715-1727(2013)
