Bicalutamide
Cat. No.：YN481385
CAS No. ：90357-06-5
规格
价格(RMB)
库存
| 产品名称: | Bicalutamide |
| CAS No.: | 90357-06-5 |
| Chemical Name: | N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-propanamide |
| Synonyms: | 比卡鲁胺 |
| 分子量: | 430.37 |
| 分子式: | C₁₈H₁₄F₄N₂O₄S |
| SMILES: | FC1=CC=C(S(=O)(CC(O)(C(NC2=CC=C(C#N)C(C(F)(F)F)=C2)=O)C)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bicalutamide 是一种具有口服活性的非甾体雄激素受体 (AR) 拮抗剂。Bicalutamide 可用于前列腺癌的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Freeman, S.N., Mainwaring, W.I.P., and Furr, B.J.A.A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334)Br. J. Cancer60(5),664-668(1989)
Masiello, D., Cheng, S., Bubley, G.J., et al.Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptorJ. Biol. Chem.277(29),26321-26326(2002)
Gao, W., Kim, J., and Dalton, J.T.Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligandsPharmacol. Res.23(8),1641-1658(2006)
Yin, D., Perera, M.A., Dalton, J.T., et al.Key structural features of nonsteroidal ligands for binding and activation of the androgen receptorMol. Pharmacol.63(1),211-223(2003)
