Enzalutamide
Cat. No.：YN481725
CAS No. ：915087-33-1
规格
价格(RMB)
库存
| 产品名称: | Enzalutamide |
| CAS No.: | 915087-33-1 |
| Chemical Name: | 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methyl-benzamide |
| Synonyms: | 恩杂鲁胺; MDV3100 |
| 分子量: | 464.44 |
| 分子式: | C₂₁H₁₆F₄N₄O₂S |
| SMILES: | S=C(N(C(C1(C)C)=O)C2=CC=C(C#N)C(C(F)(F)F)=C2)N1C3=CC(F)=C(C(NC)=O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Enzalutamide (MDV3100) 是一种雄激素受体 (androgen receptor (AR)) 拮抗剂，在 LNCaP 前列腺细胞中抑制 AR 的IC50值为 36 nM。Enzalutamide 是一种自噬 (autophagy) 激活剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Tran, C., Ouk, S., Clegg, N.J., et al.Development of a second-generation antiandrogen for treatment of advanced prostate cancerScience324(5928),787-790(2009)
Jung, M.E., Ouk, S., Yoo, D., et al.Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC)J. Med. Chem.53(7),2779-2796(2010)
Semenas, J., Dizeyi, N., and Persson, J.L.Enzalutamide as a second generation antiandrogen for treatment of advanced prostate cancerDrug Des. Devel. Ther.7,875-881(2013)
