Apalutamide
Cat. No.：YN481527
CAS No. ：956104-40-8
规格
价格(RMB)
库存
| 产品名称: | Apalutamide |
| CAS No.: | 956104-40-8 |
| Chemical Name: | 4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide |
| Synonyms: | ARN-509 |
| 分子量: | 477.43 |
| 分子式: | C₂₁H₁₅F₄N₅O₂S |
| SMILES: | O=C(NC)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Apalutamide (ARN-509) 是有效，竞争性的雄激素受体 (AR) 拮抗剂，IC50为 16 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Clegg, N.J., Wongvipat, J., Joseph, D.J., et al.ARN-509: A novel antiandrogen for prostate cancer treatmentCancer Res.72(6),1494-1503(2012)
Gupta, E., Guthrie, T., and Tan, W.Changing paradigms in management of metastatic Castration Resistant Prostate Cancer (mCRPC)BMC Urol.14,55(2014)
