11-Ketodihydrotestosterone
Cat. No.：YN481254
CAS No. ：32694-37-4
| 产品名称: | 11-Ketodihydrotestosterone |
| CAS No.: | 32694-37-4 |
| Chemical Name: | (5α,17β)-17-hydroxy-androstane-3,11-dione |
| Synonyms: | 11-KDHT; 5α-Dihydro-11-keto testosterone |
| 分子量: | 304.42 |
| 分子式: | C₁₉H₂₈O₃ |
| SMILES: | C[C@@]1(C2)[C@@H](O)CC[C@@]1([H])[C@]3([H])CC[C@@]4([H])CC(CC[C@]4(C)[C@@]3([H])C2=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) 是一种内源性类固醇，是 11β-羟基雄烯二酮的代谢产物。11-Ketodihydrotestosterone 是一种活性雄激素，也是一种有效的雄激素受体 (AR) 激动剂，对人AR的Ki为 20.4 nM，EC50为 1.35 nM。11-Ketodihydrotestosterone 在雄激素依赖性前列腺癌细胞中诱导基因调节，蛋白质表达和细胞生长。 |
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Bloem, L.M., Storbeck, K.-H., Schloms, L., et al.11β-hydroxyandrostenedione returns to the steroid arena: Biosynthesis, metabolism and functionMolecules18(11),13228-13244(2013)
Swart, A.C., and Storbeck, K.-H.11β-hydroxyandrostenedione: Downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathwayMol. Cell. Endocrinol.408,114-123(2015)
Storbeck, K.-H., Bloem, L.M., Africander, D., et al.11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer?Mol. Cell. Endocrinol.377(1-2),135-146(2013)
