EPI-001
Cat. No.：YN480056
CAS No. ：227947-06-0
规格
价格(RMB)
库存
| 产品名称: | EPI-001 |
| CAS No.: | 227947-06-0 |
| Chemical Name: | 3-[4-[1-[4-(3-chloro-2-hydroxypropoxy)phenyl]-1-methylethyl]phenoxy]-1,2-propanediol |
| Synonyms: | EPI 001,EPI001 |
| 分子量: | 394.89 |
| 分子式: | C₂₁H₂₇ClO₅ |
| SMILES: | OCC(O)COC1=CC=C(C(C)(C2=CC=C(OCC(O)CCl)C=C2)C)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EPI-001 是一种选择性雄激素受体 (AR) 的抑制剂，抑制 AR 氨基末端结构域 (NTD) 的反式激活，IC50值约 6 μM。EPI-001也是PPARγ的选择性调节剂。EPI-001在体外和体内均表现出抗肿瘤活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Andersen, R.J., Mawji, N.R., Wang, J., et al.Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptorCancer Cell17(6),535-546(2010)
