SF2523
Cat. No.：YN420020
CAS No. ：1174428-47-7
规格
价格(RMB)
库存
| 产品名称: | SF2523 |
| CAS No.: | 1174428-47-7 |
| Chemical Name: | 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(4-morpholinyl)-7H-thieno[3,2-b]pyran-7-one |
| Synonyms: | SF-2523; SF 2523 |
| 分子量: | 371.41 |
| 分子式: | C₁₉H₁₇NO₅S |
| SMILES: | O=C1C=C(N2CCOCC2)OC3=C1SC=C3C4=CC=C(OCCO5)C5=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SF2523 是一种有效的选择性PI3K抑制剂，抑制PI3Kα，PI3Kγ，DNA-PK，BRD4 和 mTOR，IC50分别为 34 nM，158 nM，9 nM，241 nM 和 280 nM。 |
| IC50和靶点: | [{name:"PI3Kα:34 nM (IC50)"},{name: "PI3Kγ:158 nM (IC50)"},{name: "BRD4 (BD1):241 nM (IC50)"},{name: "DNA-PK:9 nM (IC50)"},{name: "mTOR:280 nM (IC50)"}] |
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| Solvent & Solubility: |
Andrews, F.H., Singh, A.R., Joshi, S., et al.Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasisProc. Natl. Acad. Sci. USA114(7),E1072-E1080(2017)
