PIK-90
Cat. No.：YN420102
CAS No. ：677338-12-4
规格
价格(RMB)
库存
| 产品名称: | PIK-90 |
| CAS No.: | 677338-12-4 |
| Chemical Name: | N-(2,3-dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide |
| Synonyms: | PIK-90,PIK 90 |
| 分子量: | 351.36 |
| 分子式: | C₁₈H₁₇N₅O₃ |
| SMILES: | O=C(NC1=NC2=C(C3=NCCN13)C=CC(OC)=C2OC)C4=CC=CN=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PIK-90 是一种PI3K和DNA-PK抑制剂，抑制p110α,p110γ，和DNA-PK，IC50分别为 11, 18 和 13 nM。 |
| IC50和靶点: | [{name:"p110α:11 nM (IC50)"},{name: "p110γ:18 nM (IC50)"},{name: "p110δ:58 nM (IC50)"},{name: "p110β:350 nM (IC50)"},{name: "hsVPS34:830 nM (IC50)"},{name: "PI3KC2β:64 nM (IC50)"},{name: "PI3KC2α:47 nM (IC50)"},{name: "DNA-PK:13 nM (IC50)"},{name: "ATM:610 nM (IC50)"},{name: "PI4KIIIα:830 nM (IC50)"},{name: "PI4KIIIβ:3.1 μM (IC50)"},{name: "mTORC1:1.05 μM (IC50)"},{name: "ATR:15 μM (IC50)"}] |
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| Solvent & Solubility: |
Niedermeier, M., Hennessy, B.T., Knight, Z.A., et al.Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: A novel therapeutic approachBlood113(22),5549-5557(2009)
Fan, Q.W., Knight, Z.A., Goldenberg, D.D., et al.A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in gliomaCancer Cell9(5),341-349(2006)
Knight, Z.A., Gonzalez, B., Feldman, M.E., et al.A pharmacological map of the PI3-K family defines a role for p110α in insulin signalingCell125(4),733-747(2006)
