NU 7026
Cat. No.：YN420223
CAS No. ：154447-35-5
规格
价格(RMB)
库存
| 产品名称: | NU 7026 |
| CAS No.: | 154447-35-5 |
| Chemical Name: | 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one |
| Synonyms: | LY293646 |
| 分子量: | 281.31 |
| 分子式: | C₁₇H₁₅NO₃ |
| SMILES: | O=C1C2=CC=C3C=CC=CC3=C2OC(N4CCOCC4)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NU 7026 (LY293646) 是一种新型特异性的DNA-PK抑制剂，IC50为 0.23 μM，也抑制PI3K，IC50为 13 μM。 |
| IC50和靶点: | [{name:"DNA-PK:0.23 μM (IC50)"},{name: "PI3K:13 μM (IC50)"}] |
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Veuger, S.J., Curtin, N.J., Richardson, C.J., et al.Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1Cancer Res.63,6008-6015(2003)
Willmore, E., de Caux, S., Sunter, N.J., et al.Anovel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemiaBlood103(12),4659-4665(2004)
