Torin 2
Cat. No.：YN420146
CAS No. ：1223001-51-1
规格
价格(RMB)
库存
| 产品名称: | Torin 2 |
| CAS No.: | 1223001-51-1 |
| Chemical Name: | 9-(6-amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one |
| Synonyms: | Torin-2,Torin 2 |
| 分子量: | 432.40 |
| 分子式: | C₂₄H₁₅F₃N₄O |
| SMILES: | O=C1N(C2=C(C=C1)C=NC3=CC=C(C=C32)C4=CC=C(N=C4)N)C5=CC=CC(C(F)(F)F)=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Torin 2 是一种mTOR抑制剂，抑制细胞内 mTOR 活性，EC50为 0.25 nM，比作用于 PI3K (EC50: 200 nM) 选择性高 800 倍。体外酶实验中，Torin 2 还抑制DNA-PK，IC50为 0.5 nM。Torin 2 抑制mTORC1和mTORC2。 |
| IC50和靶点: | [{name:"mTOR:2.81 nM (IC50)"},{name: "mTOR:0.25 nM (EC50, Cell Assay)'}, 'mTORC1', 'mTORC2', {'DNA-PK:0.5 nM (IC50)"},{name: "p110γ:5.67 nM (IC50)"},{name: "PI3K-C2β:24.5 nM (IC50)"},{name: "PI3K-C2α:28.1 nM (IC50)"},{name: "hVps34:8.58 nM (IC50)"},{name: "PI3K:200 nM (EC50, Cell Assay)"},{name: "ΡΙ4Κβ:18.3 nM (IC50)'}, 'Autophagy'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Liu, Q., Wang, J., Kang, S.A., et al.Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatment of cancerJ. Med. Chem.54(5),1473-1480(2011)
Thoreen, C.C., Kang, S.A., Chang, J.W., et al.An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1J. Biol. Chem.284(12),8023-8032(2009)
