PI-103
Cat. No.：YN420021
CAS No. ：371935-74-9
规格
价格(RMB)
库存
| 产品名称: | PI-103 |
| CAS No.: | 371935-74-9 |
| Chemical Name: | 3-[4-(4-morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol |
| Synonyms: | PI103,PI 103 |
| 分子量: | 348.36 |
| 分子式: | C₁₉H₁₆N₄O₃ |
| SMILES: | OC1=CC(C2=NC3=C(C(N4CCOCC4)=N2)OC5=C3C=CC=N5)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PI-103 是一种有效的PI3K和mTOR抑制剂，抑制p110α，p110β，p110δ，p110γ，mTORC1和mTORC2，IC50分别为 8 nM，88 nM，48 nM，150 nM，20 nM 和 83 nM。PI-103 还抑制DNA-PK，IC50为 2 nM。PI-103 诱导自噬 (autophagy)。 |
| IC50和靶点: | [{name:"p110α:8 nM (IC50)"},{name: "p110β:88 nM (IC50)"},{name: "p110δ:48 nM (IC50)"},{name: "p110γ:150 nM (IC50)"},{name: "mTORC1:20 nM (IC50)"},{name: "mTORC2:83 nM (IC50)"},{name: "PI3KC2β:26 nM (IC50)"},{name: "PI3KC2α:1 μM (IC50)"},{name: "hsVPS34:2.3 μM (IC50)"},{name: "DNA-PK:2 nM (IC50)"},{name: "ATR:850 nM (IC50)"},{name: "ATM:920 nM (IC50)"},{name: "PI4KIIIβ:50 μM (IC50)"}] |
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Knight, Z.A., Gonzalez, B., Feldman, M.E., et al.A pharmacological map of the PI3-K family defines a role for p110α in insulin signalingCell125(4),733-747(2006)
Rückle, T., Schwarz, M.K., and Rommel, C.PI3Kγ inhibition: Towards an 'aspirin of the 21st century'?Nat. Rev. Drug Discov.5(11),903-918(2006)
Fan, Q.W., Knight, Z.A., Goldenberg, D.D., et al.A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in gliomaCancer Cell9(5),341-349(2006)
