PIK-75 hydrochloride
Cat. No.：YN420158
CAS No. ：372196-77-5
规格
价格(RMB)
库存
| 产品名称: | PIK-75 hydrochloride |
| CAS No.: | 372196-77-5 |
| Chemical Name: | 2-methyl-5-nitro-2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide-benzenesulfonic acid, monohydrochloride |
| Synonyms: | PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75 |
| 分子量: | 488.74 |
| 分子式: | C₁₆H₁₅BrClN₅O₄S |
| SMILES: | BrC(C=C1)=CN2C1=NC=C2/C=N/N(S(=O)(C3=C(C=CC([N+]([O-])=O)=C3)C)=O)C.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PIK-75 hydrochloride 是一种可逆的DNA-PK和p110α-选择性的抑制剂，抑制 DNA-PK，p110α和 p110γ，IC50分别为 2，5.8 和 76 nM。PIK-75 hydrochloride 抑制 p110α 效果比抑制 p110β (IC50=1.3 μM) 高 200 多倍。PIK-75 hydrochloride 诱导凋亡 (apoptosis)。 |
| IC50和靶点: | [{name:"DNA-PK:2 nM (IC50)"},{name: "p110α:5.8 nM (IC50)"},{name: "p110γ:76 nM (IC50)"},{name: "p110δ:510 nM (IC50)"},{name: "p110β:1.3 μM (IC50)"},{name: "hsVPS34:2.6 μM (IC50)"},{name: "PI3KC2β:1 μM (IC50)"},{name: "PI3KC2α:10 μM (IC50)"},{name: "mTORC1:1 μM (IC50)"},{name: "mTORC2:10 μM (IC50)"},{name: "ATM:2.3 μM (IC50)"},{name: "ATR:21 μM (IC50)"},{name: "PI4KIIIβ:50 μM (IC50)"}] |
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Fan, Q.W., Knight, Z.A., Goldenberg, D.D., et al.A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in gliomaCancer Cell9(5),341-349(2006)
Knight, Z.A., Gonzalez, B., Feldman, M.E., et al.A pharmacological map of the PI3-K family defines a role for p110α in insulin signalingCell125(4),733-747(2006)
