KU-57788
Cat. No.：YN420068
CAS No. ：503468-95-9
规格
价格(RMB)
库存
| 产品名称: | KU-57788 |
| CAS No.: | 503468-95-9 |
| Chemical Name: | 8-(4-dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |
| Synonyms: | NU7441 |
| 分子量: | 413.49 |
| 分子式: | C₂₅H₁₉NO₃S |
| SMILES: | O=C1C=C(N2CCOCC2)OC3=C1C=CC=C3C4=CC=CC5=C4SC6=C5C=CC=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KU-57788 (NU7441) 是一种高效的选择性DNA-PK抑制剂，IC50为 14 nM。 KU-57788 是 NHEJ 通路抑制剂。KU-57788 还抑制 PI3K 和 mTOR，IC50分别为 5.0 和 1.7 μM。 |
| IC50和靶点: | [{name:"DNA-PK:14 nM (IC50)"},{name: "mTOR:1.7 μM (IC50)"},{name: "PI3K:5.0 μM (IC50)'}, 'CRISPR/Cas9'] |
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| Solvent & Solubility: |
Veuger, S.J., Curtin, N.J., Richardson, C.J., et al.Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1Cancer Res.63,6008-6015(2003)
Leahy, J.J.J., Golding, B.T., Griffin, R.J., et al.Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone librariesBioorg. Med. Chem. Lett.14(24),6083-6087(2004)
Zhao, Y., Thomas, H.D., Batey, M.A., et al.Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441Cancer Res.66(10),5354-5362(2006)
