Compound 401
Cat. No.：YN420261
CAS No. ：168425-64-7
规格
价格(RMB)
库存
| 产品名称: | Compound 401 |
| CAS No.: | 168425-64-7 |
| Chemical Name: | 2-(4-morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one |
| Synonyms: | 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one |
| 分子量: | 281.31 |
| 分子式: | C₁₆H₁₅N₃O₂ |
| SMILES: | O=C1C=C(N2CCOCC2)N=C3N1C=CC4=C3C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Compound 401 是一种合成的DNA-PK(IC50=0.28 μM) 抑制剂，在体外也靶向作用于 mTOR，但对 PI3K 没有抑制效果。 |
| IC50和靶点: | [{name:"DNA-PK:0.28 μM (IC50)"},{name: "mTOR:5.3 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Griffin, R.J., Fontana, G., Golding, B.T., et al.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: Synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitroJ. Med. Chem.48(2),569-585(2005)
Ballou, L.M., Selinger, E.S., Choi, J.Y., et al.Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-α]isoquinolin-4-oneJ. Biol. Chem.282(33),24463-24470(2007)
