FLLL32
Cat. No.：YN340009
CAS No. ：1226895-15-3
| 产品名称: | FLLL32 |
| CAS No.: | 1226895-15-3 |
| Chemical Name: | (2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)]-2-propen-1-one |
| Synonyms: | FLLL32,FLLL-32,FLLL 32 |
| 分子量: | 464.55 |
| 分子式: | C₂₈H₃₂O₆ |
| SMILES: | O=C(C1(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)CCCCC1)/C=C/C3=CC=C(OC)C(OC)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FLLL32，一种姜黄素的合成类似物，是JAK2/STAT3的双重抑制剂，具有抗肿瘤癌活性。FLLL32 作用于乳腺癌细胞，可抑制 IFNα 和 IL-6 诱导的 STAT3 磷酸化。 |
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Bill, M.A., Fuchs, J.R., Li, C., et al.The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activityMol. Cancer9(165),(2010)
Lin, L., Hutzen, B., Zuo, M., et al.Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cellsCancer Res.70(6),2445-2454(2010)
Abuzeid, W.M., Davis, S., Tang, A., et al.Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analogArch. Otolaryngol. Head Neck Surg.137(5),499-507(2011)
Wu, X., Tang, W., Marquez, R.T., et al.Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signalingOncotarget7(10),11708-11723(2016)
