Ruxolitinib
Cat. No.：YN340236
CAS No. ：941678-49-5
| 产品名称: | Ruxolitinib |
| CAS No.: | 941678-49-5 |
| Chemical Name: | βR-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile |
| Synonyms: | 芦可替尼; INCB18424 |
| 分子量: | 306.37 |
| 分子式: | C₁₇H₁₈N₆ |
| SMILES: | N#CC[C@H](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ruxolitinib (INCB18424) 是有效，选择性的JAK1/2抑制剂，IC50值分别为 3.3 nM 和 2.8 nM，选择性是 JAK3 的 130 多倍。Ruxolitinib 诱导自噬 (autophagy)，通过毒性线粒体自噬 (mitophagy) 杀死肿瘤细胞。 |
| IC50和靶点: | [{name:"JAK2:2.8 nM (IC50)"},{name: "JAK1:3.3 nM (IC50)"},{name: "Tyk2:19 nM (IC50)"},{name: "JAK3:428 nM (IC50)"}] |
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| Solvent & Solubility: |
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Quintás-Cardama, A., Vaddi, K., Liu, P., et al.Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: Therapeutic implications for the treatment of myeloproliferative neoplasmsBlood115(15),3109-3117(2010)
