Filgotinib
Cat. No.：YN340208
CAS No. ：1206161-97-8
| 产品名称: | Filgotinib |
| CAS No.: | 1206161-97-8 |
| Chemical Name: | N-[5-[4-[(1,1-dioxido-4-thiomorpholinyl)methyl]phenyl][1,2,4]triazolo[1,5-ɑ]pyridin-2-yl]-cyclopropanecarboxamide |
| Synonyms: | GLPG0634 |
| 分子量: | 425.50 |
| 分子式: | C₂₁H₂₃N₅O₃S |
| SMILES: | O=C(C1CC1)NC2=NN3C(C4=CC=C(CN5CCS(CC5)(=O)=O)C=C4)=CC=CC3=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Filgotinib (GLPG0634) 是一种选择性的JAK抑制剂，能够有效抑制 JAK1，JAK2，JAK3 和 TYK2 的活性，IC50值分别为 10 nM，28 nM，810 nM 和 116 nM。 |
| IC50和靶点: | [{name:"JAK1:10 nM (IC50)"},{name: "JAK2:28 nM (IC50)"},{name: "Tyk2:116 nM (IC50)"},{name: "JAK3:810 nM (IC50)"}] |
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| Solvent & Solubility: |
Van Rompaey, L., Galien, R., van der Aar, E.M., et al.Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseasesJ. Immunol.191(7),3568-3577(2013)
