Itacitinib
Cat. No.：YN340197
CAS No. ：1334298-90-6
| 产品名称: | Itacitinib |
| CAS No.: | 1334298-90-6 |
| Chemical Name: | 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
| Synonyms: | INCB039110 |
| 分子量: | 553.51 |
| 分子式: | C₂₆H₂₃F₄N₉O |
| SMILES: | N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Itacitinib (INCB039110) 是一种有效的，选择性的JAK1抑制剂，对 人JAK1的IC50值为 2 nM。Itacitinib 对JAK1选择性是 JAK2 的 20 多倍，是 JAK3 和 TYK2 的 100 多倍。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Norman, P.Selective JAK inhibitors in development for rheumatoid arthritisExpert Opin. Investig. Drugs23(8),1067-1077(2014)
