AMG-47a
Cat. No.：YN340209
CAS No. ：882663-88-9
| 产品名称: | AMG-47a |
| CAS No.: | 882663-88-9 |
| Chemical Name: | 4-methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]-benzamide |
| Synonyms: | AMG-47a;4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide;4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide;4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6-yl |
| 分子量: | 535.56 |
| 分子式: | C₂₉H₂₈F₃N₅O₂ |
| SMILES: | O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(C3=CC4=CN=C(NCCN5CCOCC5)N=C4C=C3)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMG-47a 是一种有效的，具有口服活性的Lck抑制剂，其IC50值为 0.2 nM。AMG-47a 对VEGF2、p38α、p38α、Jak3、MLR和IL-2具有抑制作用，IC50值分别为 1 nM、3 nM、72 nM、30 nM 和 21 nM。AMG-47a 具有抗炎作用。 |
| IC50和靶点: | |
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DiMauro, E.F., Newcomb, J., Nunes, J.J., et al.Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: Synthesis, SAR, and in vivo anti-inflammatory activityJ. Med. Chem.49(19),5671-5686(2006)
Carver, J., Dexheimer, T.S., Hsu, D., et al.A high-throughput assay for small molecule destabilizers of the KRAS oncoproteinPLoS One9(8),e103836(2014)
