Ruxolitinib phosphate
Cat. No.：YN340238
CAS No. ：1092939-17-7
| 产品名称: | Ruxolitinib phosphate |
| CAS No.: | 1092939-17-7 |
| Chemical Name: | βR-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile, monophosphate |
| Synonyms: | INCB018424 phosphate |
| 分子量: | 404.36 |
| 分子式: | C₁₇H₂₁N₆O₄P |
| SMILES: | N#CC[C@H](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2.O=P(O)(O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ruxolitinib phosphate (INCB018424 phosphate) 是一种有效的JAK1/2抑制剂，IC50分别为3.3 nM/2.8 nM，比JAK3选择性高130倍。 |
| IC50和靶点: | [{name:"JAK2:2.8 nM (IC50)"},{name: "JAK1:3.3 nM (IC50)"},{name: "Tyk2:19 nM (IC50)"},{name: "JAK3:428 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Verstovsek, S.Therapeutic potential of JAK2 inhibitorsHematology Am. Soc. Hematol. Educ. Program,636-642(2009)
Quintás-Cardama, A., Vaddi, K., Liu, P., et al.Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: Therapeutic implications for the treatment of myeloproliferative neoplasmsBlood115(15),3109-3117(2010)
