Cucurbitacin I
Cat. No.：YN340270
CAS No. ：2222-07-3
| 产品名称: | Cucurbitacin I |
| CAS No.: | 2222-07-3 |
| Chemical Name: | (10α)-2,16α,20,25-tetrahydroxy-9β-methyl-19-norlanosta-1,5,23E-triene-3,11,22-trione |
| Synonyms: | Elatericin B; JSI-124; NSC-521777 |
| 分子量: | 514.65 |
| 分子式: | C₃₀H₄₂O₇ |
| SMILES: | CC(C)(C1=CC[C@@]2([H])[C@@]3(C[C@@H](O)[C@@H]([C@]3(C4)C)[C@@](C)(O)C(/C=C/C(C)(O)C)=O)C)C(C(O)=C[C@@]1([H])[C@]2(C)C4=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cucurbitacin I 是JAK2/STAT3的天然选择性抑制剂，并具有有效的抗肿瘤活性。 |
| IC50和靶点: | |
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Blaskovich, M.A., Sun, J., Cantor, A., et al.Discovery of JSI-124 (Cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in miceCancer Res.63(6),1270-1279(2003)
Nefedova, Y., Nagaraj, S., Rosenbauer, A., et al.Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacological selective inhibition of the Jak2/STAT3 pathwayCancer Res.65(20),9525-9535(2005)
Lui, V.W.Y., Yau, D.M.S., Wong, E.Y.L., et al.Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cellsCarcinogenesis30(12),2085-2094(2009)
