AT9283
Cat. No.：YN340235
CAS No. ：896466-04-9
| 产品名称: | AT9283 |
| CAS No.: | 896466-04-9 |
| Chemical Name: | N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-urea |
| Synonyms: | J-504568 |
| 分子量: | 381.43 |
| 分子式: | C₁₉H₂₃N₇O₂ |
| SMILES: | O=C(NC1CC1)NC2=CNN=C2C3=NC4=CC=C(C=C4N3)CN5CCOCC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AT9283 是一种多靶点激酶抑制剂，有效抑制Aurora A/B，JAK2/3，Abl (T315I)，和Flt3(IC50值范围为 1-30 nM)。AT9283 抑制多种实体瘤在体内外的生长和存活。 |
| IC50和靶点: | [{name:"Aurora A:3 nM (IC50)"},{name: "Aurora B:3 nM (IC50)"},{name: "JAK3:1.1 nM (IC50)"},{name: "JAK2:1.2 nM (IC50)"},{name: "ABL(T315I):4 nM (IC50)'}, 'Flt-3'] |
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Howard, S., Berdini, V., Boulstridge, J.A., et al.Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activityJ. Med. Chem.52(2),379-388(2009)
Curry, J., Angove, H., Fazal, L., et al.Aurora B kinase inhibition in mitosis: Strategies for optimising the use of aurora kinase inhibitors such as AT9283Cell Cycle8(12),1921-1929(2009)
Qi, W., Liu, X., Cooke, L.S., et al.AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomasInt. J. Cancer130(12),2997-3005(2012)
Santo, L., Hideshima, T., Cirstea, D., et al.Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomideClin. Cancer Res.17(10),3259-3271(2011)
