SAR-20347
Cat. No.：YN340017
CAS No. ：1450881-55-6
规格
价格(RMB)
库存
| 产品名称: | SAR-20347 |
| CAS No.: | 1450881-55-6 |
| Chemical Name: | 2-(2-chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-4-oxazolecarboxamide |
| Synonyms: | SAR20347 |
| 分子量: | 444.84 |
| 分子式: | C₂₁H₁₈ClFN₄O₄ |
| SMILES: | O=C(C1=C(NC2=CC=C(C(N3CCOCC3)=O)C=C2)OC(C4=C(F)C=CC=C4Cl)=N1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SAR-20347 是TYK2，JAK1，JAK2和JAK3的抑制剂，其IC50值分别为 0.6, 23, 26 和 41 nM。 |
| IC50和靶点: | [{name:"Tyk2:0.6 nM (IC50)"},{name: "JAK1:23 nM (IC50)"},{name: "JAK2:26 nM (IC50)"},{name: "JAK3:41 nM (IC50)"}] |
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| Solvent & Solubility: |
Works, M.G., Yin, F., Yin, C.C., et al.Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axisJ. Immunol.193(7),3278-3287(2014)
