Abrocitinib
Cat. No.：YN340064
CAS No. ：1622902-68-4
| 产品名称: | Abrocitinib |
| CAS No.: | 1622902-68-4 |
| Chemical Name: | N-[cis-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide |
| Synonyms: | PF-04965842 |
| 分子量: | 323.41 |
| 分子式: | C₁₄H₂₁N₅O₂S |
| SMILES: | CN([C@H]1C[C@@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Abrocitinib (PF-04965842) 是一种有效、可口服、选择性的JAK1抑制剂，对 JAK1 和 JAK2 的IC50值分别为 29 和 803 nM。Abrocitinib (PF-04965842) 可抑制 TYK2 的活性(IC50，1.253 μM) 和刺激后 STAT1，STAT3 和 STAT5 的磷酸化水平。可用于自身免疫症的研究。 |
| IC50和靶点: | [{name:"JAK1:29 nM (IC50)"},{name: "JAK2:803 nM (IC50)"},{name: "Tyk2:1253 nM (IC50)"}] |
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| Solvent & Solubility: |
Vazquez, M.L., Kaila, N., Strohbach, J.W., et al.Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A selective JAK1 clinical candidate for the treatment of autoimmune diseasesJ. Med. Chem.61(3),1130-1152(2018)
