WHI-P97
Cat. No.：YN340071
CAS No. ：211555-05-4
| 产品名称: | WHI-P97 |
| CAS No.: | 211555-05-4 |
| Chemical Name: | 2,6-dibromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
| Synonyms: | 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉 |
| 分子量: | 455.10 |
| 分子式: | C₁₆H₁₃Br₂N₃O₃ |
| SMILES: | BrC1=CC(NC2=NC=NC3=CC(OC)=C(OC)C=C32)=CC(Br)=C1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WHI-P97 是一种有效的选择性JAK-3抑制剂。WHI-P97 在动物模型中有效预防过敏性哮喘的发展。 |
| IC50和靶点: | [{name:"JAK3:11 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Sudbeck, E.A., Liu, X.P., Narla, R.K., et al.Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agentsClin. Cancer Res.5(6),1569-1582(1999)
Malaviya, R., Chen, C.-L., Navara, C., et al.Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97)J. Pharmacol. Exp. Ther.295(3),912-926(2000)
